How long does it take, if at all, to determine a reaction from hormones?
There is ALWAYS a reaction to taking cross sex exogenous hormones. If the individual has a history of gender dysphoria or as I would prefer to call it, Gender Expression Deprivation Anxiety, the primary reaction is a relaxing one. That is the individual experiences feelings of well-being as the anxiety is relieved. If a non gender dysphoric person is exposed to cross sex, exogenous hormones, the opposite occurs; a state of anxiety is induced that goes away once the hormones are no longer being taken. The time period for all of this to occur is very short, ranging from hours to no more than a few days.
The other, more physical changes take longer and are not easily reversible. If a genetic male takes estrogens, he will start to notice tenderness in his nipples in a matter of weeks as the first signs of breast development. The rest of the feminization will gradually happen over the rest of the period he continues to take the hormones. Depending on the person's age and level of male development at the start of the process, it usually takes six to twelve months before the changes are so advanced that friends and acquaintances would notice and may start to inquiry about your appearance. Of course, a spouse or lover would notice much sooner.
In genetic females that take androgens, the physical changes are far more profound and happen very quickly. Menses stop within the first or second scheduled periods and there will be a strong and profound increase in libido. Within the first few months beard growth, body hair and voice changes begin to be obvious to the casual observer. FTMs often speak of experiencing general body pain as male pattern muscles start to develop.Read More